Uromodulin gene polymorphisms in patients with cast nephropathy in multiple myeloma
نویسندگان
چکیده
منابع مشابه
Cast nephropathy in multiple myeloma.
Case report A 54-year-old man presented with one-week history of bilateral loin pain, reduced urine output and malaise. Complete blood picture showed hemoglobin of 7.6g/dL (normal: 11.5-17g/dL) Serum biochemistry showed hypercalcemia and markedly impaired renal function with creatinine measuring 1081 µmol/L (normal: 80-120). Skeletal survey showed multiple osteolytic lesions, and bone marrow as...
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Cast nephropathy is the result of coprecipitation of immunoglobulin free light chains (FLCs) with Tamm-Horsfall glycoprotein (THP). It is a hallmark of multiple myeloma that has significant consequences. Treatment strategies in the past focused on reduction of serum FLC by control of the myeloma. In this issue, Ying et al. report on their successful synthesis of a cyclized competitor peptide th...
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ژورنال
عنوان ژورنال: Terapevticheskii arkhiv
سال: 2017
ISSN: 2309-5342,0040-3660
DOI: 10.17116/terarkh201789868-71